Indapamide
Indications
Hypertension, Congestive heart failure
Adult Dose
Oral
Hypertension
Adult: 1.25-2.5 mg once daily, alone or in conjunction with other antihypertensives.
Oedema
Adult: 2.5 mg once daily increased to 5 mg daily after 1 wk if needed.
Child Dose
Safety & efficacy not established
Administration
Should be taken with food.
Contra Indications
Anuria, severe hepatic impairment.
Precautions
Pregnancy, lactation, elderly, renal impairment, fluid or electrolyte imbalance, hyperuricaemia, DM, lupus erythematosus.
Lactation: not known if excreted into breast milk, avoid
Pregnancy-Lactation
B
Pregnancy Category: B
Lactation: not known if excreted into breast milk, avoid
Interactions
Additive effect with other antihypertensive agents and diuretics. Increased chance of hypokalaemia with corticosteroids, corticotropin and amphotericin.
Potentially Fatal: Increased risk of lithium toxicity. Hypokalaemia enhances digitalis toxicity with cardiac gycosides.
Adverse Effects
1-10%
Hypotension,Palpation,Flushing,Dizziness,Lightheadedness,Vertigo,Headache,Weakness,Restlessness,Drowsiness,Fatigue,Lethargy,Malaise,Anorexia,Nausea/vomiting,Nocturia,Polyuria,Blurred vision,Rhinnorhea,Electrolyte abnormalities,Pruritus,Rash
<1%
Cutaneous vasculitis,Glycosuria,Pancreatitis
Mechanism of Action
Indapamide enhances excretion of sodium, chloride and water by interfering with the transport of sodium ions across the renal tubular epithelium.