Sodium Cromoglycate (Cromoglicic acid)

Indications

Asthma, Asthma propylaxis

Adult Dose

Adults: Inhalation Asthma prophylaxis As dry powd/ nebulising soln: 20 mg 4 times/day As aerosol:10 mg 4 times/day, up to 6-8 times/day if needed, reduced to 5 mg 4 times/day once asthma has stabilised. Additional doses may be taken before exercise.

Contra Indications

Hypersensitivity.

Precautions

Lactation, cardiac arrhythmias, hepatic or renal dysfunction.

Pregnancy-Lactation

B

Adverse Effects

Nausea, headache, dizziness, unpleasant taste, joint pain and swelling, skin rashes, aggravation of asthma, pulmonary infiltrates with eosinophilia, urticaria. Bronchospasm, wheezing, cough, nasal congestion and throat irritation following inhalation of dry powder.

Mechanism of Action

Sodium Cromoglycate inhibits degranulation of mast cells and therefore suppresses the release of histamine, leukotrienes and slow-reacting substance of anaphylaxis.