Devil’s Claw
Indications
Gout, Rheumatism, Arthritis, Osteoporosis, Back Pain, Osteoarthritis, Spondylitis.
Adult Dose
1 capsule 2-3 times daily or as per directed by the Registered Physicians.
Contra Indications
Use is prohibited in cases of stomach and duodenal ulcers. Use is not
advisable in cases of gallstones without consulting a doctor.
Pregnancy-Lactation
The safety of this capsule in pregnancy has not been studied. Therefore, it should be used with caution during pregnancy as per directed by the Registered Physicians.
Interactions
No report is available
Adverse Effects
No side effects were observed at prescribed doses.
Mechanism of Action
Devil’s Claw contains iridoid monoterpenes such as harpagoside, harpazide, procumbide;
Phenyl ethanol such as acetoside, isoacetoside; The oligosaccharide starchose and several
harpagoquinones are found.
Harpagozide: It inhibits key inflammatory mediators such as Cyclo-oxygenase-2 (COX2)
and nitric oxide synthase, reducing the production of prostaglandins & nitric oxide, both of
which are involved in pain & inflammation pathways. It blocks the NF-?B signaling
pathway, which is crucial in regulating the expression of various pro-inflammatory cytokines.
This leads to reduced inflammation & in turn, pain relief. It can reduce pain & improve
mobility in patients with low back pain & osteoarthritis.
Harpazide & Procumbide: Provides analgesic anti-inflammatory effects.
Aromatic acids: Reduce acute and neuropathic pain.