Aluminium Oxide + Magnesium Hydroxide
Indications
Hyperacidity, Flatulence, Gastric ulcer, Duodenal ulcer, Gastritis, Stomach distension
Adult Dose
Chew 1-2 tablets after meals and at bedtime as needed (up to 4 times a day).
Do not take more than 16 tablets in 24 hours
Administration
After meals and at bedtime as needed. For best results, drink a half glass of water or other liquid after each dose.
Contra Indications
Hypophosphataemia.
Precautions
Renal dysfunction, low phosphate diet, prolonged use.
Pregnancy-Lactation
Not Classi
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Adverse Effects
Diarrhoea, constipation, nausea, vomiting.
Mechanism of Action
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Magnesium hydroxide increases peristaltic activity causing osmotic retention of fluids, thus resulting in bowel evacuation. It also reduces stomach acid by reacting with hydrochloric acid to form Mg chloride.