Fusate Cream

Indications

Acne vulgaris, Skin infections, Conjunctivitis, staphylococcal infections

Adult Dose

Oral Susceptible infections Adult: 500 mg tid. May increase to 1 g tid in fulminating infections.

Child Dose

Oral Susceptible infections Child: <1 yr: About 15 mg/kg; 1-5 yr: 250 mg; 5-12 yr: 500 mg. Doses to be taken tid.

Administration

Should be taken with food.

Contra Indications

Hypersensitivity.

Precautions

Hepatic disease; monitor liver function. Neonates; pregnancy, lactation.

Pregnancy-Lactation

Not Classi

Interactions

Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.

Adverse Effects

Jaundice and liver dysfunction (reversible); GI disturbances. IV: Venospasm, thrombophloebitis and haemolysis; hypocalcaemia. SC/IM: Tissue necrosis. Topical: Rashes and irritation.

Mechanism of Action

Fusidic acid disrupts translocation of peptide subunits and elongating the peptide chain of susceptible bacteria, thus inhibiting protein synthesis.

Note

Fusate 2% Cream manufactured by Amulet Pharmaceuticals Ltd.. Its generic name is Sodium Fusidate (Fusidic Acid).