Undenatured Type-II Collagen + Hyaluronic Acid + Methylsulfonylmethane + Turmeric + Boswellia serrata

Each capsule is indicated for- • Osteoarthritis • Rheumatoid arthritis • Joint pain & inflammation • Difficulties in flexibility & mobility • Joint discomfort & stiffness (knee extension).

One capsule two times daily with meal or as directed by the physician

This combination is contraindicated in patients with known hypersensitivity to Undenatured type II Collagen, Hayaluronic Acid, Methylsulfonylmethane, Turmeric Extract or Boswellia serrata Extract.

No studies have evaluated the use of Undenatured Type II Collagen, Hayaluronic Acid, Methylsulfonylmethane, Turmeric Extract and Boswellia serrata Extract during pregnancy or lactation. It should be taken with caution and medical advice.

There is no known drug interaction with Undenatured type II Collagen, Hayaluronic Acid, Methylsulfonylmethane, Turmeric Extract and Boswellia serrata Extract

Undenatured Type II Collagen, Hayaluronic Acid, Methylsulfonylmethane, Turmeric Extract and Boswellia serrata Extract are well tolerated in recommended dose. Side eects are rare and some may feel stomach problems.

Undenatured Type II Collagen is derived from chicken sternum cartilage using a patented, low-temperature, nonenzymatic manufacturing process that preserves the natural triple helix molecular conguration and its biological activity. It contains active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of Undenatured Type II Collagen interact with Peyer's patches (lymphoid tissue) of small intestine to release collagen-specic regulatory T-cells. Collagen-specic regulatory T-cells then migrate to joint areas and prevent release of T-cells which are destructive for joint cartilage. It prevents the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inammatory cytokines resulting in reduction of inammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Hyaluronic acid is naturally present throughout the human body. In the joints, hyaluronic acid has several functions, including: Lubrication: Hyaluronic acid binds well to water, producing a viscous, jelly-like consistency. This viscous uid provides lubrication and also acts as a shock absorber within the joint. Growth of cartilage and bone: Hyaluronic acid helps in the growth and development of joint’s cartilage and bone by promoting the growth of new cells and tissues. Reducing inammation: Hyaluronic acid plays an important role in reducing joint inammation and pain caused by injury or tissue degeneration. Methylsulfonylmethane (MSM) has anti-inammatory and antioxidant eects. Sulphur, which is a major component of MSM, plays an important role in making collagen and glucosamine, both of which are vital for healthy bones and joints. In clinical study, MSM shows signicant decrease in WOMAC pain and physical function impairment. Turmeric extract contains curcumin which has anti-inammatory, antithrombotic, antioxidant, and antimicrobial activities. The anti-inammatory eects of curcumin are believed to be a result of inhibiting pro-inammatory signals such as prostaglandins, leukotrienes, and cyclooxygenase-2. In addition, curcumin has been demonstrated to suppress several pro-inammatory cytokines and mediators of their release such as tumor necrosis factor-? (TNF-?), IL-1, IL-8, and nitric oxide synthase. Boswellic acid is the active ingredient in Boswellia serrata which has signicant pharmacological activity in the treatment of inammatory diseases such as rheumatoid arthritis and other inammatory conditions. Research showed that 3-O-Acetyl-11-keto-beta-boswellic acid (AKBA), present in Boswellia serrata extract, has a powerful inhibitory eect on 5-lipoxygenase (5-LOX).