Terconazole 0.4% Vag prep

Vulvovaginal candidiasis

Vaginal Vulvovaginal candidiasis Adult: As cream: Apply intravaginally at bedtime for 7 consecutive days or for 3 consecutive days, respectively. As 80 mg supp: Admin intravaginally at bedtime for 3 consecutive days.

Hypersensitivity. Lactation.

Discontinue if irritation or flu-like symptoms develop. May damage latex or rubber contraceptives. Patients <18 yrs. Pregnancy.

C Pregnancy Category: C Lactation: unknown

May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.

Vulvovaginal burning, vulvar itching, dysmenorrhoea, genital, body and abdominal pain. Flu-like syndrome with headache, fever, chills and hypotension with doses >80 mg.

Terconazole disrupts ergosterol synthesis by binding to fungal cytochrome P450. It is active in vitro against Candida spp. and other fungi. It has some antibacterial activity in vitro but not against usual vag flora e.g, lactobacilli.