Suramin

Trypanosomiasis, TB Gambiense

Trypanosomiasis 100-200 mg (test dose) IV, then 1 g IV on days 1, 3, 7, 14, 21 TB Gambiense 10 mg/kg IV q5day to total of 12 injections May repeat after 1 month; use concomitantly with tryparsamide

Trypanosomiasis 20 mg/kg IV on days 1, 3, 7, 14, 21; not to exceed 1 g/dose

Hypersensitivity

Proteinuria and renal toxicity reported with use Avoid use in renal or hepatic impairment

Not Classi Pregnancy Category: no human studies conducted Lactation: not known if excreted in breast milk

Frequency Not Defined Vomiting Urticaria Paresthesia Peripheral neuropathy Kidney damage Blood dyscrasias Polyuria Polydipsia Pancytopenia Shock Optic atrophy

Trypanocidal activity; inhibits enzymes involved with the oxidation of reduced NADH