Pranlukast hydrate

Indications

Allergic rhinitis, Asthma

Adult Dose

Oral Allergic rhinitis, Asthma Adult: 225 mg bid.

Child Dose

Oral Allergic rhinitis, Asthma Child: 3.5 mg/kg bid. Max dose: 10 mg/kg/day (not exceeding 450 mg daily).

Contra Indications

Acute asthma attacks; hepatic impairment/cirrhosis.

Precautions

Renal impairment. Possible elevations in liver enzymes. Withdraw treatment in patients showing signs consistent with Churg-Strauss syndrome.

Pregnancy-Lactation

Not Classi

Interactions

Concurrent use with warfarin and other anticoagulants may cause an increase in prothrombin time.

Adverse Effects

Headache, increased incidence of resp tract infection, GI disturbances, induced generalized pain, fever, myalgia, arthralgia.

Mechanism of Action

Pranlukast is a selective leukotriene D4-receptor antagonist. It suppresses early and late bronchoconstrictor responses to inhaled antigen or irritants.