Podophyllotoxin 0.15%

Anogenital warts

Topical/Cutaneous Anogenital warts Adult: On a wkly basis, apply on the warts, leave for 1-6 hr then wash off. If there is no improvement after 6 wk, stop treatment. Alternatively, apply 0.5% alcoholic gel or 0.15% cream bid for 3 days but do not wash off. Repeat wkly for up to 5 wk.

Hypersensitivity; pregnancy; lactation; child.

Avoid excessive application. Avoid contact with eyes and inflamed skin. Not to be used on cervical or urethral warts.

C

Irritating to the eyes and mucous membranes; GI disturbances; thrombocytopenia, leucopenia; renal failure; hepatotoxicity; CNS effects; EEG changes; peripheral and autonomic neuropathies; local reactions.

The mechanism of action of podophyllo toxin is based on inhibiting the polymerization of tubulin and arresting the cell cycle in the metaphase.