Mepyramine Maleate 2% Topical

Pruritic skin disorders

Topical/Cutaneous Hypersensitivity reactions, Pruritic skin disorders Adult: Apply 2% cream on affected areas.

Severe liver disease; premature infants or full-term neonates; eczema (topical).

Pregnancy; lactation; severe CV disorders; asthma; drowsiness; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly; epilepsy. May affect ability to drive and operate machinery. Broken skin (topical).

Not Classi

increased effects with CNS depressants (e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics). Additive effects with other antimuscarinics (e.g. TCAs, atropine).

Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation; psychomotor impairment; headache; palpitations and arrhythmias; convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood dyscrasias; hypotension; hair loss; tinnitus.

Mepyramine is an ethylenediamine derived antihistamine with antimuscarinic and sedating properties.