Lynestrenol

Contraception, Menstrual disorders

Oral Menstrual disorders Adult: 5-10 mg daily as cyclic regimen.

May be taken with or without food.

Undiagnosed vaginal bleeding, active venous thromboembolic disorders or severe arterial disease, hepatic impairment, progestogen-dependent tumours, porphyria. Pregnancy.

CV or renal dysfunction, hypertension, epilepsy, migraine, asthma, DM, conditions which may be exacerbated by fluid retention, malabsorption syndrome, post ectopic pregnancy, functional ovarian cysts, thromboembolism. Lactation.

D

Increased metabolism and subsequent reduction in efficacy with enzyme-inducing agents e.g. carbamazepine, griseofulvin, phenobarbital, phenytoin and rifampicin. Adjustment in antidiabetic dose may be required. Potentially Fatal: May increase plasma levels and toxicity of ciclosporin.

GI disturbances, changes in appetite or weight, fluid retention, oedema, rashes, urticaria, mental depression, breast tenderness and pain, gynaecomastia, changes in libido, headache, migraine, altered menstrual cycle, irregular menstrual bleeding, changes in LFTs and serum lipid profile. Potentially Fatal: Anaphylaxis or anaphylactoid reactions.

Lynestrenol is a progestogen structurally related to norethisterone. It may be used alone or as the progestogenic component of some oral contraceptives.