Glycopyrronium Bromide (Glycopyrrolate) oral sol

Reduce chronic severe drooling, in children & adolescents aged 3 years and older.

Oral Adult >48 years : 15 ml 3 times daily at least 1 hour before or 2 hours after meals

Oral Children (3-18 years) : 5-10 ml 3 times daily at least 1 hour before or 2 hours after meals

Administer 1 hr ac or 2 hr pc High fat food reduces PO bioavailability

Hypersensitivity to glycopyrrolate or other ingredients

Pregnancy, lactation. CV disease, hyperthyroidism, hepatic or renal impairment. Enlarged prostate, diarrhoea, fever. May cause ileus or megacolon in patients with ulcerative colitis. Children and elderly.

Not Classi Pregnancy category: B Lactation: Excretion in milk unknown; use with caution

Frequency Not Defined Anticholinergic symptoms (mydriasis, hyperthermia, tachycardia, cardiac arrhythmia) Dry mouth Dry skin Anhidrosis Flushing Blurred vision Cycloplegia Photophobia Palpitation Xerophthalmia Constipation Urinary retention

Glycopyrrolate is a competitive inhibitor of acetylcholine receptors that are located on certain peripheral tissues, including salivary glands. Glycopyrrolate indirectly reduces the rate of salivation by preventing the stimulation of these receptors.