Glucosamine Hydrochloride + Chondroitin Sulfate + Undenatured Type-II Collagen
Indications
Capsule is indicated for-
• Osteoarthritis
• Rheumatoid arthritis
• Joint pain & inflammation
• Difficulties in flexibility & mobility
• Joint discomfort & stiffness (knee extension)
• Impaired joint function
• Strenuous exercise & sports.
Adult Dose
Orally 1 capsule daily with water or as directed by the physician.
The safety and effectiveness under the age of 18 years have not been established.
Contra Indications
This combination is contraindicated in patients with known hypersensitivity to Glucosamine, Chondroitin, chicken or egg.
Precautions
Glucosamine is a naturally occurring amino sugar of cartilage that provides the basic raw material needed by the body to manufacture joint cartilage. Chondroitin is another naturally occurring mucopolysaccharide of cartilage that stimulates cartilage production, inhibits cartilage destroying enzymes, draws fluid to the cells and helps lubricate the joints. Glucosamine and Chondroitin work synergistically together to help stimulate the production and regeneration of connective tissues (e.g., cartilage, bone, tendon, skin, mucous membrane, blood vessels etc.). Undenatured Type II Collagen is derived from chicken sternum cartilage using a patented, low-temperature, nonenzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured Type II Collagen molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of Undenatured Type II Collagen interact with Peyer's patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen-specific regulatory T-cells then migrate to joint areas and prevent release of T-cells which are destructive for joint cartilage. It prevents the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding.
Pregnancy-Lactation
No studies have evaluated the use of Undenatured Type II Collagen, Glucosamine and Chondroitin during pregnancy or lactation.
Interactions
There is no known drug interaction with Undenatured type II Collagen, Glucosamine and Chondroitin.
Adverse Effects
Undenatured Type II Collagen, Glucosamine & Chondroitin are well tolerated in recommended dose. Side effects are rare and some may feel stomach problems.