Gallamine Triethiodide
Indications
Aid controlled ventilation, Muscle relaxant
Adult Dose
Intravenous
Muscle relaxant in general anaesthesia; Aid controlled ventilation
Adult: Test dose: 20 mg may be given before anesth to determine drug sensitivity. Initially, 80-120 mg via IV inj, further doses of 20-40 mg may be given as required.
Child Dose
Intravenous
Muscle relaxant in general anaesthesia; Aid controlled ventilation
Child: 1.5 mg/kg.
Neonates: 600 mcg/kg.
Contra Indications
Severe renal impairment. Hypersensitivity to iodine. Mysasthenia gravis.
Precautions
Careful dose titration and monitoring of the degree of block are required to prevent overdosage.
Pregnancy-Lactation
Not Classi
Interactions
Lidocaine, procainamide, quinidine, and verapamil may enhance the block. Clindamycin can prolong the action of muscle relaxants. Apnoea may be prolonged when used with polymyxins. Anticholinesterases or long-term treatment with corticosteroids may antagonise the action of gallamine.
Adverse Effects
Tachycardia, increased BP.
Mechanism of Action
Gallamine triethiodide is a benzylisoquinolinium competitive neuromuscular blocker. It is used to produce muscle relaxation in general anaesthesia during surgical procedures and to aid controlled ventilation.