Gallamine Triethiodide

Indications

Aid controlled ventilation, Muscle relaxant

Adult Dose

Intravenous Muscle relaxant in general anaesthesia; Aid controlled ventilation Adult: Test dose: 20 mg may be given before anesth to determine drug sensitivity. Initially, 80-120 mg via IV inj, further doses of 20-40 mg may be given as required.

Child Dose

Intravenous Muscle relaxant in general anaesthesia; Aid controlled ventilation Child: 1.5 mg/kg. Neonates: 600 mcg/kg.

Contra Indications

Severe renal impairment. Hypersensitivity to iodine. Mysasthenia gravis.

Precautions

Careful dose titration and monitoring of the degree of block are required to prevent overdosage.

Pregnancy-Lactation

Not Classi

Interactions

Lidocaine, procainamide, quinidine, and verapamil may enhance the block. Clindamycin can prolong the action of muscle relaxants. Apnoea may be prolonged when used with polymyxins. Anticholinesterases or long-term treatment with corticosteroids may antagonise the action of gallamine.

Adverse Effects

Tachycardia, increased BP.

Mechanism of Action

Gallamine triethiodide is a benzylisoquinolinium competitive neuromuscular blocker. It is used to produce muscle relaxation in general anaesthesia during surgical procedures and to aid controlled ventilation.

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