Etomidate

Anaesthesia

General Anesthesia Induction 0.3-0.6 mg/kg IVP over 30-60 sec

General Anesthesia Induction <10 years: Safety and efficacy not established >10 years: 0.3-0.6 mg/kg IVP over 30-60 sec

IV Administration Inject undiluted by direct IV injection over 30-60 sec; do not administer by prolonged IV infusion Inject into large forearm vein

Hypersensitivity. Reduced or at risk of reduced adrenocortical function. Porphyria.

Opioid analgesics or benzodiazepines may be given as premedications to reduce risk of convulsions. Not to be admin by prolonged infusion. Pre-existing epilepsy. Elderly and child <10 yrs. Pregnancy and lactation. Lactation: Not known if excreted in breast milk; use caution

C Pregnancy category: C Lactation: Not known if excreted in breast milk; use caution

Antipsychotics, sedatives or opioids; calcium-channel blockers.

>10% Transient injection site pain (30-80%),Skeletal muscle movements, mainly myoclonic (32%),Opsoclonus (20%),Adrenal suppression 1-10% Hiccups <1% Apnea (duration: 5-90 seconds),Arrhythmias,Hyperventilation,HTN,Hypotension,Hypoventilation,Laryngospasm,Nausea/vomiting,Oxygen desaturation,Snoring (may be associated with partial upper airway obstruction)

Etomidate is a carboxylated imidazole. It is a sedative and hypnotic agent used commonly for induction anaesthesia.