Eflornithine Hydrochloride Monohydrate

Indications

Reduction of Facial Hair in Women

Adult Dose

Topical Reduction of Facial Hair in Women Apply to affected area twice daily at least 8 hours apart

Child Dose

Topical Reduction of Facial Hair in Women >12 years: Apply to affected area twice daily at least 8 hours apart

Contra Indications

Hypersensitivity

Precautions

Discontinue if sensitivity occurs Lactation: Not known whether distributed into breast milk; use caution

Pregnancy-Lactation

C

Adverse Effects

Acne,Pseudofolliculitis barbae,Burning,Stinging,Dry, and/or tingling skin,Erythema,Anorexia,Neutropenia,Rash,Pruritus,Alopecia

Mechanism of Action

May inhibit ornithine decarboxylase (ODC), an enzyme that catalyzes biosynthesis of intracellular polyamines required for cell division & differentiation, which in turn can affect hair growth