Diphenhydramine + Phenylephrine

Cold/Congestion

Cold/Congestion Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies 4 teaspoonfuls (ie, 20 mL) PO q4hr PRN

Cold/Congestion Indicated for symptoms occurring with a cold, hay fever, or other upper respiratory allergies <6 years: Do not use 6-12 years: 2 teaspoonfuls (ie, 10 mL) PO q4hr PRN 12 years or older: 4 teaspoonfuls (ie, 20 mL) PO q4hr PRN

Hypersensitivity Repeated administration in patients with anemia or cardiac, pulmonary, or renal disease Do not use with MAOIs or for 2 weeks after discontinuing MAOIs

Phenylephrine may increase blood pressure Diphenhydramine Marked drowsiness may occur; avoid other sedating drugs and alcohol Paradoxical excitability reaction may occur, especially in children Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction

C Pregnancy category: B Lactation: Drug enters breast milk; contraindicated

Frequency Not Defined Hypertension Severe peripheral and visceral vasoconstriction Reflex tachycardia Dizziness Drowsiness Excitability Headache Restlessness Tremor GI disturbances

Diphenhydramine: Histamine H1-receptor antagonist Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia