Dexrabeprazole Sodium

Indications

Peptic ulcer, Gastro-oesophageal reflux disease (GERD)

Adult Dose

Oral Adult 10 mg once daily in the morning for 4 to 8 weeks depending upon response of patient. Maintenance of healing of GERD may suffice with a lower dose of 5 mg once daily.

Administration

Dexrabeprazole sodium tablets should not be chewed or crushed, but should be swallowed whole.

Contra Indications

Hypersensitivity to dexrabeprazole

Precautions

General: Symptomatic response to therapy does not preclude the presence of gastric malignancy. Pregnancy, lactation

Pregnancy-Lactation

Not Classi

Interactions

No clinically significant interactions with drugs metabolized by the CYP450 system. An interaction with compounds (e.g. Ketoconazole) which are dependent on gastric pH for absorption may occur due to the magnitude of acid suppression.

Adverse Effects

Headache, diarrhoea, abdominal pain, asthenia, flatulence, rash & dry mouth.

Mechanism of Action

Dexrabeprazole is the chirally pure R (+) enantiomer of racemate Rabeprazole. Dexrabeprazole is a proton pump inhibitor.

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