Dexrabeprazole Sodium
Indications
Peptic ulcer, Gastro-oesophageal reflux disease (GERD)
Adult Dose
Oral
Adult
10 mg once daily in the morning for 4 to 8 weeks depending upon response of patient.
Maintenance of healing of GERD may suffice with a lower dose of 5 mg once daily.
Administration
Dexrabeprazole sodium tablets should not be chewed or crushed, but should be swallowed whole.
Contra Indications
Hypersensitivity to dexrabeprazole
Precautions
General: Symptomatic response to therapy does not preclude the presence of gastric malignancy. Pregnancy, lactation
Pregnancy-Lactation
Not Classi
Interactions
No clinically significant interactions with drugs metabolized by the CYP450 system.
An interaction with compounds (e.g. Ketoconazole) which are dependent on gastric pH for absorption may occur due to the magnitude of acid suppression.
Adverse Effects
Headache, diarrhoea, abdominal pain, asthenia, flatulence, rash & dry mouth.
Mechanism of Action
Dexrabeprazole is the chirally pure R (+) enantiomer of racemate Rabeprazole. Dexrabeprazole is a proton pump inhibitor.