Dexchlorpheniramine

Indications

Allergy Symptoms

Adult Dose

Oral Allergy Symptoms 2 mg PO 4-6 hourly

Child Dose

Oral Allergy Symptoms 2-6 years: Syrup: 0.5 mg PO 4-6 hourly 6-11 years: (syrup) 1 mg PO 4-6 hourly >12 years: As adults; (syrup) 2 mg PO 4-6 hourly

Elderly Dose

Dose at lower end of dosage range (2 mg PO q4-6hr) or administer less frequently Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria) Avoid use in elderly because of high incidence of anticholinergic effects Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

Pregnancy-Lactation

B Pregnancy Category: B Lactation: excretion in milk unknown/not recommended

Interactions

Contraindicated (0) Serious (10) calcium/magnesium/potassium/sodium oxybates eluxadoline metoclopramide intranasal olopatadine intranasal pitolisant ropeginterferon alfa 2b sodium oxybate sofpironium topical tranylcypromine zuranolone

Mechanism of Action

Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract

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