Colestipol

Hyperlipidaemia

Oral Hyperlipidaemias Adult: As tab: Initially, 2 g 1-2 times daily, increase by 2 g 1-2 times daily at 1-2 month intervals. Maintenance: 2-16 g daily in 1 or divided doses. As granules for susp: Initially, 5 g 1-2 times daily, increased in 5-g increments at intervals of 1 month. Max: 30 g daily in 1-2 divided doses.

Mix dry form in water/fluids to avoid inhalation or esophageal distress Mix granules in fluids or food; take before meals Do not crush, chew, or cut tablets Take 1 tablet at a time; swallow with water or other fluids

Hypersensitivity to colestipol Bowel obstruction

Increased risk of bleeding due to hypoprothrombinemia from vitamin K deficiency May interfere with fat absorption, and decrease absorption of fat-soluble vitamins (A, D, E, K) May worsen pre-existing constipation Take other medications 1 hr before or 4 hr after colestipol If significant increase in triglycerides, consider dose reduction, discontinuation or alternatives Monitoring Parameters Determine serum cholesterol and triglyceride concentrations prior to and regularly during therapy.

C Pregnancy Category: C Lactation: use caution; may interfere with vitamin absorption in infants

May interfere w/ absorption of folic acid, oral phosphate supplements, and fats, preventing absorption of fat-soluble vit. Decreased absorption of tetracycline, penicillin G, hydrochlorothiazide, furosemide or gemfibrozil. May bind digoxin in the GI tract and impair its absorption. Decreased and/or delayed GI absorption of propranolol. May decrease serum concentration of mycophenolic acid. Contraindicated (1) mycophenolate

>10% Gastrointestinal (mostly) Constipation 1-10% Stomach pain Belching Nausea/vomiting Flatulance Diarrhea Dizziness Anxiety Vertigo Fatigue Drowsiness Frequency Not Defined Heartburn Steatorrhea Malabsorption of fat-soluble vitamins Gallstones Dysphagia GI bleeding Cholecystitis Peptic ulceration Transient esophageal obstruction

Colestipol binds w/ bile acids in the intestine to form an insoluble complex which is excreted in faeces, resulting in increased faecal loss of bile acid-bound LDL cholesterol.