Clemastine

Allergic Rhinitis, Urticaria, Angioedema

Oral Allergic Rhinitis 1.34 mg 2 times daily; not to exceed 8.04 mg/day for syrup or 2.68 mg/24 hours for tablets Urticaria 2.68 mg PO 1-3 times daily; not to exceed 8.04 mg/day Angioedema 2.68 mg PO 1-3 times daily; not to exceed 8.04 mg/day Other Indications & Uses Perennial & seasonal allergic & vasomotor rhinitis, relief of symptoms from colds, urticaria, angioedema, anaphylactic reactions, pruritus, allergic conjunctivitis

Oral Allergic Rhinitis <6 years old: 0.05 mg/kg/day as clemastine base or 0.335-0.67 mg/day clemastine fumarate (0.25-0.5 mg base/day) divided q8-12hr; not to exceed 1.34 mg (1 mg base) 6-12 years old: 0.67-1.34 mg clemastine fumarate (0.5-1 mg base) q12hr; not to exceed 4.02 mg/day (3 mg/day base) >12 years old: 1.34 mg 2 times daily; not to exceed 8.04 mg/day for syrup or 2.68 mg/24 hours for tablets Urticaria <6 years old: 0.05 mg/kg/day as clemastine base or 0.335-0.67 mg/day clemastine fumarate (0.25-0.5 mg base/day) divided q8-12hr; not to exceed 1.34 mg (1 mg base) 6-12 years old: 0.67-1.34 mg clemastine fumarate (0.5-1 mg base) q12hr; not to exceed 4.02 mg/day (3 mg/day base) >12 years old: 2.68 mg PO 1-3 times daily; not to exceed 8.04 mg/day

Allergic Rhinitis 1.34 mg PO q12hr; not to exceed 8.04 mg/day for syrup or 2.68 mg/24 hours for tablets Urticaria 2.68 mg PO qDay-q8hr; not to exceed 8.04 mg/day Angioedema 2.68 mg PO qDay-q8hr; not to exceed 8.04 mg/day

Documented hypersensitivity Lower respiratory disease, eg, asthma (controversial) Preemies & neonates Nursing women

Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction, history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, and hypertension Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating appliances, machinery, etc Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients

Not Classi There is no available data on clascoterone cream use in pregnant women to evaluate a drug associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. There is no data regarding the presence of Clascoterone or metabolite in human milk or the effects on milk production and breastfed infant.

Has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers) MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines Contraindicated (0) Serious (11) calcium/magnesium/potassium/sodium oxybates eluxadoline isocarboxazid lonafarnib metoclopramide intranasal olopatadine intranasal pitolisant sodium oxybate sofpironium topical tranylcypromine zuranolone

Frequency Not Defined CNS depression Drowsiness Sedation ranging from mild drowsiness to deep sleep (most frequent) Dizziness Lassitude Disturbed coordination Muscular weakness Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common Epigastric distress Anorexia Nausea Vomiting Diarrhea Constipation Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare Eczema, pruritus, inflammation, papular rash, erythema on exposed skin may occur with topical formulation Tachycardia, palpitation ECG changes (eg, widened QRS) Arrhythmias (eg, extrasystole, heart block) Hypotension Hypertension Dizziness, sedation, and hypotension may occur in geriatric patients Dryness of mouth, nose, and throat Dysuria Urinary retention Impotence Vertigo Visual disturbances Blurred vision Diplopia; tinnitus Acute labyrinthitis Insomnia Tremors Nervousness Irritability Facial dyskinesia Tightness of the chest Thickening of bronchial secretions Wheezing Nasal stuffiness Sweating Chills Early menses Toxic psychosis Headache Faintness Paresthesia Agranulocytosis Hemolytic anemia Leukopenia Thrombocytopenia Pancytopenia

Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract