Citric Acid + Potassium Citrate

Prevention of gout and kidney stones, Urine alkalinization, Renal tubular acidosis

Urinary Alkalinization Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated Usual dose: 15-30 mL PO diluted with 1 glass of water QID (after meals and at bedtime)

Urinary Alkalinization Indicated for long-term maintenance of an alkaline urine (eg, patients with uric acid and cystine calculi of the urinary tract), especially when the administration of sodium salts is undesirable or contraindicated Usual dose: 5-15 mL PO diluted with one-half glass of water QID (after meals and at bedtime)

Dilute oral solution in water according to directions, followed by additional water, if desired Proper dilution may help prevent gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations Palatability enhanced if chilled

Severe renal impairment with oliguria or azotemia Untreated Addison's disease Adynamia episodica hereditaria Acute dehydration Heat cramps Anuria Severe myocardial damage Hyperkalemia from any cause Hypersensitivity to any ingredient

The solution should be used with caution in patients with low urinary output. It should be diluted adequately with water to minimize the possibility of gastrointestinal injury associated with the oral ingestion of concentrated potassium salt preparations; and preferably, to take each dose after meals. Large doses may cause hyperkalemia and alkalosis, especially in the presence of renal disease.

Not Classi Pregnancy Not studied Lactation Not studied; unknown if normal potassium ion content of human milk affected by therapy

Frequency Not Defined Hyperkalemia Alkalosis This solution is generally well tolerated without any unpleasant side effects when given in recommended doses to patients with normal renal function and urinary output. However, as with any alkalinizing agent, caution must be used in certain patients with abnormal renal mechanisms to avoid development of hyperkalemia or alkalosis. Potassium intoxication causes listlessness, weakness, mental confusion, tingling of the extremities, and other symptoms associated with a high concentration of potassium in the serum.

Potassium citrate is absorbed and metabolized to potassium bicarbonate and this acts as a systemic alkalizer .