Chlorpheniramine + Pseudoepedrine
Indications
Relief of Cold, Fever
Adult Dose
Relief of Cold & Flu Symptoms
Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg
PO q4-6hr
Child Dose
Relief of Cold & Fever
6-12 Years Old
Chlorpheniramine maleate 2 mg and pseudoephedrine HCl 30 mg PO q4-6hr
>12 Years Old
Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr
Contra Indications
Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer
Precautions
Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine
Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates
Pregnancy-Lactation
Not Classi
Pregnancy
Unknown whether therapy will harm an unborn baby; do not use without doctor's advice if pregnant
Lactation
Unknown whether chlorpheniramine and pseudoephedrine passes into breast milk or if it could harm a nursing baby; antihistamine and decongestants may slow breast milk production; do not use without doctor's advice if breast-feeding a baby
Interactions
Contraindicated (15)
dihydroergotamine
dihydroergotamine inhaled
dihydroergotamine intranasal
ergoloid mesylates
ergonovine
ergotamine
isocarboxazid
linezolid
methylergonovine
phenelzine
procarbazine
rasagiline
selegiline
selegiline transdermal
tranylcypromine
Adverse Effects
Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing
Mechanism of Action
Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.
Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.