Chlorpheniramine + Pseudoepedrine

Indications

Relief of Cold, Fever

Adult Dose

Relief of Cold & Flu Symptoms Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr

Child Dose

Relief of Cold & Fever 6-12 Years Old Chlorpheniramine maleate 2 mg and pseudoephedrine HCl 30 mg PO q4-6hr >12 Years Old Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr

Contra Indications

Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

Precautions

Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates

Pregnancy-Lactation

Not Classi Pregnancy Unknown whether therapy will harm an unborn baby; do not use without doctor's advice if pregnant Lactation Unknown whether chlorpheniramine and pseudoephedrine passes into breast milk or if it could harm a nursing baby; antihistamine and decongestants may slow breast milk production; do not use without doctor's advice if breast-feeding a baby

Interactions

Contraindicated (15) dihydroergotamine dihydroergotamine inhaled dihydroergotamine intranasal ergoloid mesylates ergonovine ergotamine isocarboxazid linezolid methylergonovine phenelzine procarbazine rasagiline selegiline selegiline transdermal tranylcypromine

Adverse Effects

Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.

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