Cetirizine eye prep

Indications

Allergic conjunctivitis

Adult Dose

Allergic Conjunctivitis Indicated for ocular itching associated with allergic conjunctivitis Instill 1 drop in each affected eye BID (approximately 8 hours apart).

Child Dose

Allergic Conjunctivitis Indicated for ocular itching associated with allergic conjunctivitis <2 years: Safety and efficacy not established >2 years: Instill 1 drop in each affected eye BID (approximately 8 hours apart).

Precautions

Contamination of Tip and Solution. To prevent contaminating the dropper tip and solution, advise patients not to touch the eyelids or surrounding areas with the dropper tip of the bottle or tip of the single-use container. Keep the bottle closed when not in use Advise patient to not wear contact lenses if their eye is red Do not instill drops while wearing contact lenses; remove contacts before instillation; may be reinserted 10 minutes after administration; benzalkonium chloride (preservative) may be absorbed by soft contact lenses Not for treatment of contact lens-related irritation

Pregnancy-Lactation

Not Classi Pregnancy No adequate or well-controlled studies of cetirizine ophthalmic in pregnant women Use in pregnancy only if potential benefit justifies potential risk to fetus Lactation Unknown if ophthalmic cetirizine distributed in human breast milk; orally administered cetirizine is excreted in human breast milk Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for the drug, and any potential adverse effects on the breastfed infant from the drug or from the underlying maternal condition

Adverse Effects

1-10% Hyperemia (1-7%) Instillation site pain (1-7%) Reduced visual acuity (1-7%)

Mechanism of Action

Histamine-1 receptor antagonist; inhibits histamine release from mast cells, decreases chemotaxis, and inhibits eosinophil activation