Carboprost Tromethamine

Pregnancy termination in the 2nd trimester (Abortion), Postpartum Uterine Bleeding

Intramuscular Pregnancy termination in the 2nd trimester/Abortion Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days. Intramuscular Postpartum haemorrhage Adult: Initially, 250 mcg by deep in. May be repeated every 15-90-min. Max: 2 mg.

RENAL IMPAIRMENT advises avoid.

HEPATIC IMPAIRMENT advises avoid in active hepatic disease.

Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.

Potent oxytocic agent; use strict aderence to recommended dosing Only medically-trained personnel should administer the product in a hospital setting that can provide immediate care and acute surgical facilities History of glaucoma or raised IOP Asthma, hypertension/hypotension, cardiovascular disease Transient fever observed with treatment possibly as a result of carboprost's effect on hypothalamic thermoregulation Caution in patients with anemia, jaundice, renal impairment, hepatic impairment diabetes or epilepsy To decrease GI side effects pretreatment or concomitant use with antiemetic and antidiarrheal agents recommended Not for IV Rare cases of cardiovascular collapse reported with prostaglandins

C Pregnancy Category: C Lactation: Excretion in milk unknown

May potentiate effect of other oxytocics.

Nausea (1/3 patients), Vomiting (~2/3 patients),Diarrhea (~2/3 patients) Nervousness,Epistaxis,Sleep disorder,Hyperthermia,Flushing,Asthma,Wheezing,Coughing,Chest pain,Hypertension,Syncope,Palpation,Tachycardia,Chest tightness,Anxiety,Chills/shivering,Dizziness,Drowsiness,Dystonia,Faintness,Headache,Lethargy,Lightheadedness,Vertigo,Rash,Breast tenderness,Dysmenorrhea-like pain,Hot flashes,Dry throat.Taste alterations,Uterine bleeding (excessive) Local: injection site pain Backache,Leg cramps,Muscular pain,Parethesia,Blurred vision,Eye pain,Eyelid twitching,Tinnitus,Bronchospasm,Dyspnea,Hiccups

Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis.