Butoconazole vaginal prep

Vulvovaginal candidiasis

Vaginal Vulvovaginal candidiasis Adult: As 2% cream: Apply approx 5 g intravaginally for 3 consecutive nights or as a single dose. May need to extend use for 6 days in pregnant women (2nd and 3rd trimester only)

Hypersensitivity to drug 1st trimester of pregnancy

Hypersensitivity to other azoles Women w/ recurrent infections or those having 1st-time vag yeast infection. Childn <12 yr. Patient Counselling May weaken latex or rubber products (e.g. condoms, vag contraceptive diaphragms), do not use w/in 72 hr of treatment. Avoid contact w/ eyes.

C Pregnancy Category: C Lactation: not known if excreted in breast milk; use caution

Frequency Not Defined Vulvovaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping. Severe reversible thrombocytopenia. Rarely, headache, urinary frequency and burning, vulvovaginal discharge, irritation, stinging and odor.

Butoconazole, a synthetic azole antifungal, is usually fungistatic in action but may have growth phase-dependent fungicidal activity at high concentrations or against very susceptible organisms. It exerts its fungistatic activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against gm+ve organisms.