Brompheniramine + Dextromethorphan + Pseudoephedrine

Nasal Congestion, Cough

Oral Relief of Nasal Congestion & Cough Syrup: 2 mg/10mg/30mg)/5mL 2 teaspoonfuls (10 mL) every 4 hours; not to exceed 6 doses/day Syrup: (3 mg/30mg/50mg)/5mL 1 teaspoonful (5 mL) every 4 hours; not to exceed 4 doses/day

Relief of Nasal Congestion & Cough Syrup: 2 mg/10mg/30mg)/5mL <6 months: Safety and efficacy not established 6 months to 2 years: As directed by physician 2-6 years: 1/2 teaspoonful (2.5 mL) PO every 4 hours; not to exceed 6 doses/day 6-12 years: 1 teaspoonful (5 mL) PO every 4 hours; not to exceed 6 doses/day >12 years: 2 teaspoonfuls (10 mL) PO every 4 hours; not to exceed 6 doses/day Syrup: (3 mg/30mg/50mg)/5mL <6 years: As directed by physician 6-12 years: 2.5 mL PO every 6 hours prn; not to exceed 4 doses/24 hr >12 years: 5 mL PO every 6 hours prn; not to exceed 4 doses/24 hr

Hypersensitivity Acute asthma attack Severe hypertension Coronary artery disease Narrow-angle glaucoma Symptomatic prostate hypertrophy Bladder-neck obstruction Stenosing peptic ulcer

Brompheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate Pseudoephedrine: Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure

C Pregnancy category: C Lactation: excreted in breast milk/not recommended Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

ent Handout Dosing & Uses Adult Pediatric Dosage Forms & Strengths brompheniramine/dextromethorphan/pseudoephedrine oral syrup (2 mg/10mg/30mg)/5mL (Bromfed DM) (3 mg/30mg/50mg)/5mL (Bromdex D) oral elixir (1 mg/5mg/15mg)/5mL (Bromaline DM) Relief of Nasal Congestion & Cough Bromaline DM <6 years: As directed by physician 6-12 years: 2 teaspoonful (10 mL) PO q4hr; not to exceed 4 doses/day >12 years: 4 teaspoonfuls (20 mL) PO q4-6hr; not to exceed 4 doses/day Bromfed-DM <6 months: Safety and efficacy not established 6 months to 2 years: As directed by physician 2-6 years: 1/2 teasponful (2.5 mL) PO q4hr; not to exceed 6 doses/day 6-12 years: 1 teaspoonful (5 mL) PO q4hr; not to exceed 6 doses/day >12 years: 2 teaspoonfuls (10 mL) PO q4hr; not to exceed 6 doses/day Bromdex D <6 years: As directed by physician 6-12 years: 2.5 mL PO q6hr prn; not to exceed 4 doses/24 hr >12 years: 5 mL PO q6hr prn; not to exceed 4 doses/24 hr Interactions Interaction Checker Enter a drug name to check for any interactions. Type a drug, OTC, or herbal name + brompheniramine/dextromethorphan/pseudoephedrine All InteractionsSort By: Severity Contraindicated (15) dihydroergotamine dihydroergotamine inhaled dihydroergotamine intranasal ergoloid mesylates ergonovine ergotamine isocarboxazid linezolid methylergonovine phenelzine procarbazine rasagiline selegiline selegiline transdermal tranylcypromine

Frequency Not Defined Dizziness Drowsiness Dry mouth, throat, and nose Thickening of mucus in nose or throat GI disturbances Arrhythmia Palpitations Convulsion Excitability Tremor Weakness

Brompheniramine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity and penetrates CNS, which causes pronounced tendency to induce sedation Pseudoephedrine: Stimulates alpha-adrenergic receptors causing bronchodilation & vasoconstriction Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla