Brompheniramine + Dextromethorphan + Phenylephrine

Relief of Cold Symptoms

Oral Relief of Cold Symptoms 4 teaspoons (20 mL) 4 hourly; not to exceed 120 mL/24 hr

Oral Relief of Cold Symptoms <6 years Not recommended 6-12 years 2 teaspoons (10 mL) PO 4 hourly >12 years 4 teaspoons (20 mL) PO 4 hourly

Contraindications Hypersensitivity Newborn infants, premature infants Nursing mothers Severe hypertension Severe coronary artery disease or ischemic heart disease Use within 14 days of MAO inhibitor Narrow-angle glaucoma Urinary retention Peptic ulcer During asthma attack Treatment of lower respiratory tract conditions, including asthma

Brompheniramine: May cause significant confusional symptoms; not for administration to premature or full-term neonates Dextromethorphan: Do not take for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; may decrease respiration rate Phenylephrine: Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis

Not Classi Pregnancy Animal reproduction studies not conducted; also not known whether drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; medication should be given to a pregnant woman only if clearly needed Lactation Because of higher risk of intolerance of antihistamines in small infants generally, and in newborns and prematures in particular, this medication is contraindicated in nursing mothers

MAO inhibitors prolong and intensify anticholinergic effects of antihistamines; antihistamines may have additive effects with alcohol and other CNS depressants, eg, hypnotics, sedatives, tranquilizers, antianxiety agents Drinking alcohol with this medication can cause side effects Contraindicated (11) iobenguane I 123 isocarboxazid linezolid phenelzine phenelzine procarbazine rasagiline selegiline transdermal safinamide selegiline tranylcypromine

Frequency Not Defined Dizziness Drowsiness Dry mouth, throat, and nose Thickening of mucus in nose or throat GI disturbances Reflex tachycardia Excitability Restlessness Headache Hypertension Severe peripheral and visceral vasoconstriction

Brompheniramine: Competitively blocks histamine from binding to H1 receptors; significant antimuscarinic activity and penetrates CNS, which causes pronounced tendency to induce sedation Dextromethorphan: Cough suppressant that acts centrally on the cough center in medulla Phenylephrine: Vasoconstrictor & decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue; shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia