Bismuth Subcitrate

Gastric and duodenal ulceration, H.pylori infection, Peptic ulcers

Adult: PO Benign gastric and duodenal ulceration 240 mg twice daily for 4-8 wk. H.pylori infection W/ other drugs: 120 mg 4 times/day for 2 wk.

Renal impairment: Moderate-severe impairment: Avoid use.

Moderate-severe renal insufficiency. Pregnancy, child <14 yr.

Monitor renal function regularly. Lactation: Poorly absorbed in to system circulation

Not Classi

Food, milk, antacids, tetracyclines and H2-receptor antagonists reduce activity of drug.

Darkening of tongue or stools. Nausea, vomiting, bone and joint toxicity. Potentially Fatal: Possibility of bismuth poisoning and fatal encephalopathy in patients with renal impairment or if given over prolonged periods. Renal failure and liver damage.

Bismuth subcitrate is used in the management of gastric and duodenal ulcers and specifically against H.pylori as part of a triple drug regimen. It exerts bactericidal action against H.pylori which is accepted to be the causative factor in chronic gastritis and duodenal ulcer..