Biotin
Indications
Biotin is indicated in hair loss, weak, brittle, splitting or soft nails, eczema & dermatitis.
Adult Dose
Biotin dose varies depending on disease condition and age group. Generally 1-3 Softgel Capsule per day or as advised by the physician. In children Biotin deficiency affects between 1 week and 2 years of age and usually exhibit seizures, hypotonia, developmental delay, ataxia, hyperventilation and coma. In this case, 5-10 Softgel Capsules (1 mg) should be taken daily after mixing the inner content of the softgel capsules with water or any kind of juice or as advised by the physician.
Contra Indications
Contraindicated in patients with known hypersensitivity to any of the ingredients.
Precautions
Taking biotin supplements might interfere with the results of many different blood lab tests. Biotin can cause falsely high or falsely low test results. This might lead to missed or incorrect diagnoses.
Pregnancy-Lactation
Sufficient clinical data is not available to use in pregnant women and lactating mother.
Interactions
There are indications that anticonvulsant drugs lower the plasma level of biotin. Antibiotic use may decrease the biotin contribution to the body made by the microflora of the large intestine. Excessive consumption of raw egg whites interferes with biotin absorption.
Adverse Effects
Well tolerated in recommended dose. No biotin toxicity has been reported in individual supplemented with as much as 200 mg orally or 20 mg intravenously per day.
Mechanism of Action
Biotin is an essential vitamin that is also known as vitamin B7 or vitamin H. It is
involved in vital physiological function like fatty acid synthesis, amino acid
catabolism and gluconeogenesis. It acts as a cofactor in the enzymatic carboxylation
of pyruvate and acetyl-CoA. Biotin in uences the growth and di erentiation
of epidermal cells and is therefore important for the formation and renewal
of the skin, hair and nails. It functions as a coenzyme for mitochondrial carboxylases
in hair roots and improves the keratin structure.