Betahistine Dihydrochloride
Indications
Meniere's disease, tinnitus and/or progressive loss of hearing, vertigo, dizziness.
Adult Dose
Adult:
Initially, 8-16 mg tid.
Maintenance: 24-48 mg daily.
Administration
Should be taken with food.
Contra Indications
Phaeochromocytoma. Porphyria.
Precautions
Active peptic ulcer, bronchial asthma, pregnancy and lactation.
Pregnancy-Lactation
C
Interactions
May antagonise antihistamines. May decrease bronchodilator effects of beta-2 agonists.
Adverse Effects
Rash, pruritus, urticaria, dyspepsia, nausea, peptic ulcer disease, headache, dizziness, insomnia.
Mechanism of Action
Betahistine improves the microcirculation in the labyrinth which reduces endolymphatic pressure.