Bepotastine Besilate 1.5% Eye prep

Allergic conjunctivitis

Ophthalmic solution Allergic Conjunctivitis Instill one drop into the affected eye(s) twice a day.

Ophthalmic solution Allergic Conjunctivitis <2 years old: Safety & efficacy not established >2 years old: Administer as in adults; Instill one drop into the affected eye(s) twice a day.

Hypersensitivity.

Remove contact lenses prior to instillation; benzalkonium chloride may be absorbed by soft contact lenses To minimize contaminating the dropper tip and solution, advise the patient not to touch the eyelids Store at room temp; protect from light & excessive heat Keep the bottle tightly closed when not in use Do not wear contact lenses if the eye is red

Not Classi Pregnancy There are no available human data for use during pregnancy to inform any drug-associated risks; oral administration of bepotastine besilate to pregnant rats or rabbits during organogenesis or during pre/postnatal period did not produce adverse embryofetal or offspring effects at clinically relevant systemic exposures; maternal toxicity was observed in rabbits at lowest dose administered, 20 mg/kg/day (215 times the maximum recommended human ophthalmic dose, RHOD, on a mg/m² basis) Lactation There are no data on human milk, effects on breastfed infant or milk production; developmental and health benefits of breastfeeding should be considered, along with mother’s clinical need for therapy, and any potential adverse effects on breastfed infant

>10% Mild taste disturbance 1-10% Ocular irritation,Headache,Nasopharyngitis

Bepotastine is direct H1-receptor antagonist and an inhibitor of the release of histamine from mast cells.