Anthralin (Dithranol) topical

Psoriasis

Psoriasis 1% cream: Rub cream once daily well into psoriatic lesions in the skin until absorbed; avoid applying excessive quantity 0.5% scalp cream: Apply as directed after washing hair and remove by washing or showering

Hypersensitivity Acute or actively inflamed psoriatic eruptions

Avoid contact with eyes or mucous membranes If redness observed reduce frequency of application or discontinue therapy May stain fingernails, hair, or fabrics Use with caution in patients with extensive and prolonged applications

C Pregnancy Category: C Lactation: Excretion in milk unknown/not recommended

Frequency Not Defined Allergic reactions around surrounding uninvolved skin Temporary discoloration of skin Lesion soreness Staining of hair, skin, and fingernails

Not fully understood Inhibits cell proliferation putatively through inhibition of DNA synthesis as well as from its strong reducing properties Anti-psoriatic action may be partly through inactivating epidermal 12-lipoxygenase & reducing levels of endothelial cell adhesion molecules which are markedly elevated in psoriasis