Amorolfine topical

Indications

Tinea Pedis, Tinea cruris, Tinea corporis, Tinea manuum, Tinea anguinalis, Tinea versicolor, Onychomycosis

Adult Dose

Topical/Cutaneous Skin fungal infections Adult: As 0.25% cream: Apply once daily for at least 2-3 weeks (up to 6 weeks for foot infections). Continue for 3-5 days after cure is attained. Nail fungal infections Adult: As 5% lacquer: Paint onto the affected nail 1-2 times weekly after filing and cleansing. Continue until nail has regenerated and the affected areas are cured. Treatment duration: Approx 6 months (fingernail) or 9-12 months (toenail).

Contra Indications

Hypersensitivity

Precautions

A systemic or local allergic reaction could possibly occur after use of this cream. If this happens, the cream should be stopped immediately and medical advice should be sought. Remove the cream carefully by cleaning the skin. The cream should not be reapplied. Children, Pregnancy and lactation. Avoid contact with eyes, ears, mucous membranes, and surrounding areas around the nail.

Pregnancy-Lactation

Not Classi Amorolfine Hydrochloride cream should not be used during pregnancy and lactation unless clearly necessary. Breast feeding women must not use the cream in the breast area.

Adverse Effects

Hypersensitivity reactions, skin irritation, erythema, pruritus, contact dermatitis, urticaria, blister. Rarely, burning sensation, severe skin reactions, nail disorder (e.g. nail discoloration, onycholysis, onychorrhexis).

Mechanism of Action

Amorolfine, a morpholine derivative, is highly active in vitro against numerous pathogenic and opportunistic fungi. It alters fungal cell membranes by interfering w/ sterol biosynthesis.