Pancil Tablet

Intermittent claudication, Peripheral vascular disease

Oral Intermittent Claudication, Peripheral vascular disease Adult: 100 mg bid. May reduce dose in patients taking enzyme inhibitors concurrently.

Renal Impairment CrCl< 25 mL/min: Use caution

Hepatic Impairment Moderate to severe: Use caution

Should be taken on an empty stomach. Take at least ½ hr before or 2 hr after meals.

Heart failure; known predisposition to bleeding; history of ventricular arrhythmias; QT interval prolongation; severe renal impairment; moderate to severe hepatic impairment.

Cilostazol is contraindicated in patients with heart failure of any severity. Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with the pharmacologic effect have caused decreased survival compared to placebo patients with class III-IV heart failure. Risks of tachycardia, palpitation, tachyarrhythmia or hypotension. Risks of exacerbations of angina pectoris or myocardial infarction in patients with a history of ischemic heart disease Left ventricular outflow tract obstruction has been reported in patients with sigmoid-shaped interventricular septum Risks of thrombocytopenia or leukopenia progressing to agranulocytosis: monitor platelets and white blood cell counts Avoid use in patients with hemostatic disorders or active pathologic bleeding

C Pregnancy category: C Lactation: Excretion in milk unknown; not recommended

Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol. Contraindicated (1) abrocitinib Serious (42) antithrombin alfa antithrombin III apalutamide apixaban argatroban aspirin rectal bivalirudin caplacizumab carbamazepine ceritinib cimetidine clarithromycin dalteparin enoxaparin enzalutamide erythromycin base erythromycin ethylsuccinate erythromycin lactobionate erythromycin stearate esomeprazole fexinidazole fluconazole fluvoxamine fondaparinux gemfibrozil heparin idelalisib isoniazid ivosidenib ketoconazole levoketoconazole lonafarnib lopinavir mifepristone modafinil nefazodone omeprazole protamine rifabutin rifampin St John's Wort tucatinib

>10% Headache (27-34%),Diarrhea (12-19%),Abnormal stools (12-15%),Infection (10-14%),Rhinitis (7-12%),Pharyngitis (7-10%) 1-10% Dizziness (9-10%),Palpitations (5-10%),Peripheral edema (7-9%),Back pain (6-7%),Dyspepsia (6%),Abdominal pain (4-5%),Tachycardia (4%),Increased cough (3-4%),Myalgia (2-3%),Atrial fibrillation (<2%),CHF (<2%),MI (<2%),Hematemesis (<2%),Ecchymosis (<2%),Blood in eye (<2%),Epistaxis (<2%),Hemoptysis (<2%),Nausea Frequency Not Defined Decreased platelet aggregation,Agranulocytosis,Aplastic anemia,Leukopenia,Thrombocytopenia,Stevens-Johnson syndrome

Cilostazol is a reversible, selective inhibitor of phosphodiesterase-III (PDE-III), thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. Increase in cAMP in platelets and blood vessels leads to inhibition of platelet aggregation and vasodilation. Cilostazol also inhibits adenosine uptake into cells, which augments the cAMP-elevating effect of PDE-III inhibition.

Pancil 100mg Tablet manufactured by Drug International Ltd.. Its generic name is Cilostazol.