Naz Eye Drops

Fungal corneal ulcers, Fungal keratitis, Fungal eye infections

Adult: 1 - 2 drops to be instilled into the affected eye 5 times daily.

The drug is contraindicated in patients with hypersensitivity to azoles.

Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than C. albicans.

D

May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam). Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.

This drug is generally well tolerated. Eosinophillia has been reported in some patients.

Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp.

Naz Eye Drops manufactured by Reman Drug Laboratories Ltd.. Its generic name is Fluconazole 0.3% Eye prep.