Cino Plus Suppository

Pruritus ani, Haemorrhoids, Anal fissure, Proctitis

Adult: Apply onto the affected area in the morning and evening and after each stool. As suppository: Insert 1 suppository in the morning and evening and after each stool.

Complete heart block; pyogenic infection at or near the skin. Application to inflamed or infected tissues or to damaged skin mucosa; instillation into the middle ear.

Elderly; debilitated patients; child; epilepsy; impaired cardiac conduction or respiratory function; shock; hepatic impairment; myasthenia gravis. Do not to rub or touch the eye while anaesthesia persists. Avoid application for prolonged periods and to extensive areas. Pregnancy, lactation.

Not Classi Pregnancy The safe use of topical corticosteroids during pregnancy has not been fully established.

Restlessness; excitement; nervousness; paraesthesias; dizziness; tinnitus; blurred vision; nausea; vomiting; muscle twitching; tremors; convulsions; hypotension; bradycardia; arrhythmias; cardiac arrest.

Cinchocaine prevents or diminishes nerve impulse conduction near to the site of admin. It also has membrane-stabilising effect owing to decrease of permeability of the nerve cell to sodium ions. Hydrocortisone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Its anti-inflammatory action is due to the suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability. It may also be used as replacement therapy in adrenocortical insufficiency. Neomycin is an aminoglycoside antibiotic. It binds to 30S ribosomal subunits of bacterial ribosome thus inhibiting protein synthesis and generating errors in genetic code transcription causing cell death. It acts against many gram-negative aerobes and some gram-positive aerobes. It lacks activity against fungi, viruses and most anaerobic bacteria. Esculin improves skin vasculature and is effective in the management of cellulitis.

Cino Plus 5 mg + 10 mg + 5 mg + 10 Suppository manufactured by Acme Laboratories Ltd.. Its generic name is Cinchocaine Hydrochloride + Esculin + Hydrocortisone + Neomycin Sulphate (Rectal prep).