Eclo Plus Ointment

Psoriasis, Burns, Acne vulgaris, Eczema, Dyskeratosis, Ichthyosis, Warts, Hyperkeratosis, Corn, Callus, Seborrhea, Scaly skin disease, Hair loss, Sweating feet, Dermatitis

Adult: Topical Acne; Hyperkeratotic and scaling skin conditions As 2-6% Salicylic Acid preparation: Apply a thin layer of this ointment to the affected skin areas 3 times/day.

Hypersensitivity

Not for prolonged use in high concentrations and on large areas of the body. Impaired peripheral circulation or diabetes. Avoid broken skin, mouth, eyes, mucous membranes and anogenital region.

Not Classi Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. The relevance of this finding to human beings has not been established. The safe use of Clobetasol Propionate during lactation has not been established. However, the administration of Clobetasol Propionate during pregnancy and lactation should only be considered if the expected benefit to the mother is greater than any possible risk to the fetus. Drugs of this class should not be used extensively in pregnant patients in large amounts or for prolonged periods of time. Whilst there are no known contra-indications to the use of Salicylic Acid ointment during pregnancy and lactation, the safety has not been established. Salicylic Acid ointment shold therefore be used with caution.

Clobetasol Propionate: Increased systemic exposure w/ CYP3A4 inhibitors (eg ritonavir & itraconazole).

Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension. Dermal and epidermal atrophy esp on the face, steroid purpura

Clobetasol Propionate high potency corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.

Eclo Plus .05% Ointment manufactured by General Pharmaceuticals Ltd.. Its generic name is Clobetasol Propionate + Salicylic Acid topical.