Pantrol Tablet

Osteoarthritis, Rheumatoid arthritis, Pain

Oral Osteoarthritis Adult: Initially, 12.5 mg once daily. Max: 25 mg/day. Pain relief Adult: Initially, 50 mg once daily followed by daily doses of 25-50 mg. Max: 50 mg/day. Treatment duration >5days is not recommended. Rheumatoid arthritis Adult: 25 mg daily. Max: 25 mg/day. Hepatic Impairment Max: 12.5 mg/day.

Hypersensitivity. Severe renal impairment.

Hepatic dysfunction, pregnancy and lactation. History of ulcer disease or GI bleeding. Elderly or debilitated patients. Prolonged treatment, smoking and alcoholism may increase risk of GI bleeding. Ischaemic heart disease.

C Pregnancy Category C, D (in 3rd trimester or near delivery)

Mouth ulcers, chest pain, weight gain, atopic eczema, muscle cramps, diarrhoea, headache, nausea; upper respiratory tract infection, hypertension, ischaemia, dyspepsia, epigastric discomfort, heart burn, nausea, sinusitis, back pain, headache, bronchitis, urinary tract infections. Potentially Fatal: Renal failure; nephrotoxicity; MI.

Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of (rofecoxib) is believed to be due to inhibition of prostaglandin synthesis, via inhibition of cyclooxygenase-2 (COX-2).

Pantrol 25mg Tablet manufactured by Drug International Ltd.. Its generic name is Rofecoxib.