Nobac Tablet

Susceptible infections, Gonococcal urethritis, Acute uncomplicated cystitis

Oral Susceptible infections Adult: 400 mg bid. Acute uncomplicated cystitis in women; Gonococcal urethritis in men Adult: 800 mg as single dose. IV Influsion Adult: 400 mg in 100 or 250 ml of 5% dextrose slow infusion over an hour bid.

Renal impairment: Dose reduction may be necessary.

Should be taken with food. Take w/ meals.

Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.

Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.

Not Classi

Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.

Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.

Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.

Nobac 400mg Tablet manufactured by Ibn Sina Pharmaceutical Ind. Ltd.. Its generic name is Pefloxacin.