Coziflex Capsule

• Osteoarthritis • Rheumatoid arthritis • Joint pain & inflammation • Difficulties in flexibility & mobility • Joint discomfort & stiffness (knee extension) • Impaired joint function • Strenuous exercise & sports

One capsule daily with water.

Contraindicated in patients with known hypersensitivity to chicken or egg.

People who are allergic to other types of collagen should not use Undenatured Type II Collagen.

Lack of scienti c evidence on the use of Undenatured Type II Collagen during pregnancy or lactation.

Not known.

Undenatured Type II Collagen is generally well tolerated in recommended dose. Over dose may cause constipation and headache.

Undenatured Type II Collagen has unique mechanism of action. Undenatured Type II Collagen molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of Undenatured Type II Collagen interact with Peyer's patches (lymphoid tissue) of small intestine to release collagen-specific requlatory T-cells. Collagen-speci c regulatory T-cells then migrate tojoint areas and prevent release of T-cells. Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of in ammatory cytokines resulting in reduction of in ammation, halting the erosion of joint cartilage and promote cartilage rebuilding.

Coziflex 40mg Capsule manufactured by Drug International Ltd.. Its generic name is Undenatured Type II Collagen.