Silyforte Capsule

• Jaundice • Infectious hepatitis • Fatty Liver • Liver cirrhosis • Drug-induced hepatitis

1 capsule 2-3 times daily or as advised by the registered physician.

No known contraindications.

Hepatoprotective; reduces serum gamma glutamyl transpeptidase (GGT) and transaminases (ALT, AST); reduces triglyceride in serum; normalizes serum-bilirubin and BSP retention; reduces malondialdehyde concentration in serum; increases superoxide dismutase (SOD) activity in erythrocytes and lymphocytes; reduces cytotoxic lymphocytes in blood; reduces procollagen-III peptide in serum.

No known restrictions.

The standardized preparation has occasionally caused a mild laxative effect.

Milk thistle’s hepatoprotective mechanism of action is due to its flavonolignan content • Silymarin scavenges pro-oxidant free radicals, increases glutathione production by the liver, intestines and stomach. Semi-purified extract of milk thistle increases activity of SOD and glutathione peroxidase in human erythrocytes in vitro, which may explain its protective effect against free radicals and its stabilizing effect on red blood cell membrane. • Silymarin stimulates the action of nucleolar polymerase A, resulting in an increase in ribosomal protein synthesis, thereby stimulating regenerative ability of the liver and formation of new hepatocytes. Based on molecular modeling, silibinin appears to initiate a steroid hormone by binding competitively to RNA-polymerase I, resulting in enzyme activity stimulation. • Silymarin alters the structure of the outer cell membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell. Stabilizes cell membranes by decreasing phospholipid turnover rate and blocking penetration of liver toxins (such as phalloidin, alpha-amanitin) into the cell. Isolated silibinin selectively inhibits leukotriene formation by Kupffer cells of the liver. Isolated silychristin (silymarin II) inhibits peroxidase and lipoxygenase. Hepatoprotective effect may be due to silymarin’s inhibition of lipid peroxidation and modulation of hepatocyte Ca2+. • Anti-inflammatory and anti-arthritic actions are due to silymarin’s inhibition of 5-lipoxygenase. • Silymarin increases biliary excretion and endogenous pool of bile salts by stimulating synthesis of hepatoprotective bile salts such as betamuricholate and ursodeoxycholate.

Silyforte 87.50 mg Capsule manufactured by Alien Pharma. Its generic name is Milk Thistle Extract.