AmiClean Tablet

Sodium Thiosulfate
15mg
Amico Laboratories Ltd.
Pack size100's pack
Retail Price0.95

Indications

Calcium urolithiasis, Cyanide poisoning, Secondary Preventive Treatment for Calciphylaxis in Dialysis Patients

Adult Dose

Oral A 2 M (molar) solution can be prepared with 74.4 g in 150 mL free water; 2.6 g can be given orally daily or 3 times a week. Dose is limited by diarrhea.

Contra Indications

Oedematous sodium-retaining conditions.

Precautions

May irritate eyes, skin and respiratory tract.

Pregnancy-Lactation

C Pregnancy Category: C

Interactions

Decreases toxicity of cisplatin through rapid chemical inactivation of its platinum component.

Adverse Effects

Osmotic disturbances. Oral: catharsis (at high doses).

Mechanism of Action

Thiosulfate is sulfur donor utilized by rhodenase to convert cyanide to less toxic thiocyanate. Cisplatin toxicity: Na-thiosulfate combines w/ cisplatin to form a complex nontoxic to both normal/cancerous cells. Increases solubility of calcium.

Note

AmiClean 15mg Tablet manufactured by Amico Laboratories Ltd.. Its generic name is Sodium Thiosulfate.