Nafgal Cream

Skin fungal infections, treatment of interdigital tinea pedis, tinea cruris, and tinea corporis

Topical/Cutaneous Skin fungal infections Adult: As hydrochloride: Apply sufficient amount of cream once daily or gel bid, morning and evening. Treatment duration: Tinea cruris and tinea corporis: 2-4 wk; tinea pedis: 4-6 wk; severe infections: May require prolonged treatment.

Apply a thin layer to the affected areas plus half inch margin of healthy surrounding skin

Hypersensitivity.

Avoid contact with eyes, nose, mouth and other mucous membranes. Avoid use of occlusive dressings or wrappings. Discontinue use if irritation occurs. Pregnancy and lactation.

B Pregnancy: There are no available data in pregnant women to inform the drug-associated risk for major birth defects and miscarriage; in animal reproduction studies, no adverse effects on embryofetal development were seen at oral doses administered during period of organogenesis up to 18 times maximum recommended human dose (MRHD) in pregnant rats or subcutaneous doses administered during period of organogenesis up to 2 times the MRHD in pregnant rats or 4 times the MRHD in pregnant rabbits Lactation: There is no information available on presence of drug in human milk, effects of drug on breastfed infant, or effects of drug on milk production; lack of clinical data during lactation precludes clear determination of risk of drug to infant during lactation; consider development and health benefits of breastfeeding along with mother’s clinical need for drug and any potential adverse effects on breastfed infant from drug or from underlying maternal condition

Burning, stinging, dryness, redness, pruritus, local irritation, rash, skin tenderness.

Naftifine is a synthetic allylamine antifungal that selectively inhibits the enzyme squalene monooxygenase resulting in reduced synthesis of the primary sterol, ergosterol, within the fungal membrane. It appears to have both fungicidal and fungistatic activity.

Nafgal 2 gm/100 gm Cream manufactured by Navana Pharmaceuticals Ltd.. Its generic name is Naftifine Topical.