Adnix Tablet

Giardiasis, Cryptosporidiosis

Oral Giardiasis; Cryptosporidiosis Adult: 500 mg every 12 hr for 3 days.

Oral Giardiasis; Cryptosporidiosis Child: 1-3 yr: 100 mg(5 ml) every 12 hr; 4-11 yr: 200 mg(10ml) every 12 hr; >12 yr: 500 mg every 12 hr. All doses to be taken for 3 days.

Should be taken with food.

Hypersensitivity.

Renal and hepatic impairment. Pregnancy and lactation. Children <1 yr.

B

May possibly interact with highly protein-bound drugs e.g. warfarin.

1-10% Headache (1%),Abdominal pain (8%),Diarrhea (2%),Nausea (3%),Chromaturia (2%),Vomiting (1%) <1% Increased ALT,Anorexia,Appetite increased,Creatinine increased,Diaphoresis,Dizziness,Eye discoloration (pale yellow),Fever,Flatulence,Infection,Malaise,Pruritus,Thinitis,Salivary glands enlarged,Urine discoloration

Nitazoxanide is an antiprotozoal agent. Both nitazoxanide and its active metabolite (tizoxanide) interfere with the pyruvate:ferredoxin 2-oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic metabolism in susceptible organisms.

Adnix 500 mg Tablet manufactured by Alco Pharma Limited. Its generic name is Nitazoxanide.