Bolt Gel

Mild to moderate anti-inflammatory and analgesic topical preparation for the symptomatic, relief of muscular pain and stiffness, sprains and strains, and pain due to rheumatic and non-serious arthritic conditions.

Topical Adult Gel: Two to six inches (5 -15 cm) to be applied to the affected area up to 4 times a day.

Keep away from the eyes. Not to be used on large areas of skin, broken or sensitive skin, infected skin, eczema or on mucous membranes. Not to be used on children under 12 years of age. Hypersensitivity to the active substance(s) or to any of the excipients listed in section Hypersensitivity to aspirin or other non-steroidal anti-inflammatory drugs (including when taken by mouth) especially where associated with a history of asthma. Not to be used on the breast area during lactation

Instruct patients not to smoke or go near naked flames – risk of severe burns. Fabric (clothing, bedding, dressings etc) that has been in contact with this product burns more easily and is a serious fire hazard. Washing clothing and bedding may reduce product build-up but not totally remove it. This medicine contains fragrance (rosemary oil) with citral, eugenol, geraniol, linalool, citronellol and limonene which may cause allergic reactions. For external use only.

Not Classi Pregnancy Not to be used during the first trimester or during late pregnancy. Breastfeeding Not to be used on the breast area during lactation.

It is possible that excessive use of topical salicylates may increase the effect of coumarin anticoagulants. It is therefore advisable that caution be exercised with patients who are taking coumarin anticoagulants. Salicylic acid may increase skin permeability for other topically applied medications.

Skin and subcutaneous tissue disorders Uncommon: Local skin reactions/irritations (e.g. redness, burning sensation or rashes).

Mucopolysaccharide polysulphate is a non-steroidal drug recognised as having: • Anti-inflammatory activity: through a weak inhibitory effect of PGE2 synthesis and an indirect effect on LTB4 production based on in vitro studies. • Anti-coagulant activity: as a heparinoid. • Thrombolytic activity: through potentiation of urokinase activity. • Anti-exudatory activity: through inhibition of hyaluronidase. Salicylic acid, a non-steroidal anti-inflammatory drug, is employed in the formulation for its keratolytic activity; and also has anti-inflammatory and analgesic properties.

Bolt 0.2%+2% Gel manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Mucopolysaccharide Polysulphate + Salicylic Acid.