Rapiflo Capsule
Silodosin
8mg
Square Pharmaceuticals PLC.
| Pack size | 20's Pack |
|---|---|
| Retail Price | 25.00 |
Indications
Treating the signs and symptoms of enlarged prostate (benign prostatic hyperplasia [BPH]).
Adult Dose
Benign Prostatic Hyperplasia
Adults
PO 8 mg once daily with a meal.
Hepatic Impairment
Mild-to-moderate impairment (Child-Pugh class A or B): Dose adjustment not necessary
Severe Impairment: (Child-Pugh class C): Contraindicated (not studied)
Renal Dose
Renal Impairment
CrCl <50 mL/min: Dose adjustment not necessary
CrCl 30-50 mL/min: 4 mg PO qDay
CrCl <30 mL/min: Contraindicated
Contra Indications
Hypersensitivity.
Precautions
Impaired hepatic & renal function. Start treatment w/ a low dose (2 mg/dose).
Pregnancy-Lactation
B
Pregnancy Category: B; not indicated in women
Lactation: Unknown if distributed in breast milk; not indicated in women
Interactions
Ketoconazole, digoxin.
Adverse Effects
>10%
Retrograde ejaculation (28%)
1-10%
Diarrhea (3%),Headache (2%),Insomnia ((1-2%),Dizziness (3%),Orthostatic hypotension (3%; increased in patients >65 years),Nasopharyngitis (2%),Nasal congestion (2%),Sinusitis (1-2%)
Mechanism of Action
Selectively blocks postsynaptic alpha-1 adrenoreceptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.
Note
Rapiflo 8mg Capsule manufactured by Square Pharmaceuticals PLC.. Its generic name is Silodosin.