Ocutrex Ear Drops

Bacterial Ear Infections

Otic/Aural Otitis externa Adult: Instill 2-3 drops into the ear bid-tid.

Renal impairment: Dose reduction may be required.

Hepatic impairment: Dose reduction may be required.

History of hypersensitivity to the drug; Perforated ear drum. Herpes simplex and other virul conditions of the ear, mycosis.

Avoid prolonged use. Discontinue immediately if local hypersensitivity reactions occur.

C

Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Potentially Fatal: Increases the effect of oral anticoagulants, oral hypoglycaemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function.

Ear drops: Ototoxicity.

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.

Ocutrex 0.5% Ear Drops manufactured by Beximco Pharmaceuticals Ltd.. Its generic name is Chloramphenicol Ear drops.