Somopin Tablet

Anxiety disorders, Depression, Insomnia

Oral Depression/Anxiety Adult: Initiate at low dose (25 mg/day); gradually titrate upward every 5-7 days Dosage range: 25-300 mg/day PO, up to 150 mg/day as single dose If dose exceeds 150 mg/day, divide q12hr Hepatic impairment: Use lower dose and adjust gradually for depression; Insomnia (Silenor) Sleep maintenance 3-6 mg PO within 30 minutes before bedtime; not to exceed 6 mg/day Hepatic impairment/debilitated patients: 3 mg PO within 30 minutes before bedtime Elderly Insomnia Sleep maintenance Starting dose: 3 mg PO within 30 minutes before bedtime May increase to 6 mg PO HS if clinically indicated Depression/Anxiety Lower initial dose (ie, 10 mg/day) and adjust gradually; 10-25 mg PO qHS May increase by 10-25 mg increments q3Day for inpatients and weekly for outpatients if tolerated

<12 years old: Not recommended

May be taken with or without food.

Hypersensitivity; mania, glaucoma, neonates (topical); lactation.

Epilepsy, CV disease, pregnancy, history of urinary retention, glaucoma; gradual withdrawal. May impair ability to drive or operate machinery. Lactation: Enters breast milk; not recommended (AAP states "may be of concern")

Not Classi Pregnancy category: Not available Lactation: Enters breast milk; not recommended (AAP states "may be of concern")

Methylphenidate may increase plasma doxepin levels. Potentially Fatal: Potentiates hypertensive action of sympathomimetics. Increased anticholinergic effects with MAOIs. Additive CNS effects with anticholinergics, CNS depressants and alcohol.

Sedation, fatigue, weakness, lethargy,Dry mouth,Constipation,Blurred vision,Headache,Agitation,Insomnia,Anxiety,Nausea, vomiting,Sweating,Confusion, extrapyramidal symptoms (EPS), dizziness, paresthesia,Orthostatic hypotension, ECG changes, tachycardia,Increased LFTs,Tinnitus,Sexual dysfunction,Rash,Seizure,Agranulocytosis,Thrombocytopenia,Eosinophilia,Leukopenia,SIADH

Doxepin inhibits serotonin and norepinephrine re-uptake by the presynaptic neuronal membrane increasing its synaptic conc in the CNS.

Somopin 3mg Tablet manufactured by Incepta Pharmaceuticals Ltd.. Its generic name is Doxepin.